USA TODAY Sports’ Week 6 NFL picks: Cowboys-Eagles, Bills-Chiefs early season monster matchups

Week 6 of the NFL season comes bearing gifts – serving up two of the most savory matchups of a still-young 2022 season.

Sunday afternoon, the Buffalo Bills and Kansas City Chiefs will meet for the fifth time in two years. The Bills cruised 38-20 in last year’s regular-season contest at Arrowhead Stadium, but it remains the only time Josh Allen has beaten Patrick Mahomes. Buffalo is favored Sunday, but the real test likely won’t come until January – when the Bills have fallen at K.C. the last two postseasons.

Sunday night, the Dallas Cowboys get a shot at dealing the Philadelphia Eagles their first loss of the 2022 season. A Dallas win would also mean a first-place tie atop the NFC East. A Philly victory would give the Iggles their first 6-0 start since the 2004 team advanced to (and lost) Super Bowl 39. 

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(Odds provided by Tipico Sportsbook)

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