Ultra-Processed Foods Linked With Heart Disease, Bowel Cancer and Death

Newly published research links high consumption of ultra-processed foods and increased risks of cardiovascular disease, colorectal cancer, and death.

Findings add further evidence in support of policies that limit ultra-processed foods.

Two large research studies published by The BMJ last week find links between high consumption of ultra-processed foods and increased risks of cardiovascular disease, bowel (colorectal) cancer, and death.

The results provide more evidence in favor of policies that limit ultra-processed foods and instead advocate eating unprocessed or minimally-processed foods to improve global public health.

They also underscore the opportunity to reformulate dietary guidelines worldwide, by paying greater attention to the degree of processing of foods along with nutrient-based recommendations.

Ultra-processed foods include packaged baked goods and snacks, fizzy drinks, sugary cereals, and ready-to-eat or heat products. They often contain high levels of added sugar, fat, and/or salt, but lack vitamins and fiber.

Although previous studies have linked ultra-processed foods to higher risks of obesity, cholesterol, high blood pressure, and some cancers, few studies have assessed the association between ultra-processed food intake and colorectal cancer risk, and results are mixed due to limitations in study design and sample sizes.

In the first new study, researchers investigated the association between the consumption of ultra-processed foods and the risk of colorectal cancer in US adults.

Their findings are based on 46,341 men and 159,907 women from three large studies of US health professionals. Their dietary intake was assessed every four years using detailed food frequency questionnaires.

Foods were grouped by degree of processing and rates of colorectal cancer were measured over a period of 24-28 years, taking into account medical and lifestyle factors.

Results show that men in the highest fifth of ultra-processed food consumption had a 29% higher risk of developing colorectal cancer compared with those in the lowest fifth of consumption. This remained significant after further adjustment for body mass index and dietary quality.

No link was observed between overall ultra-processed food consumption and the risk of colorectal cancer among women. However, higher consumption of meat/poultry/seafood-based ready-to-eat products and sugar-sweetened beverages among men — and ready-to-eat/heat mixed dishes among women — was associated with an increased risk of colorectal cancer.

In the second new study, scientists analyzed two food classification systems in relation to mortality — the Food Standards Agency Nutrient Profiling System (FSAm-NPS), used to derive the color-coded Nutri-Score front-of-pack label, and the NOVA scale, which evaluates the degree of food processing.

Their findings are based on 22,895 Italian adults (average age 55 years; 48% men) from the Moli-sani Study, investigating genetic and environmental risk factors for heart diseases and cancer.

Both the quantity and quality of food and beverages consumed were assessed and deaths were measured over a 14-year period (2005 to 2019), taking into account underlying medical conditions.

Results showed that those in the highest quarter of the FSAm-NPS index (least healthy diet) had a 19% higher risk of death from any cause and a 32% higher risk of death from cardiovascular disease compared with the lowest quarter (healthiest diet).

Risks were similar when the two extreme categories of ultra-processed food intake on the NOVA scale were compared (19% and 27% higher for all-cause and cardiovascular mortality, respectively).

A significant proportion of the excess mortality risk associated with a poor diet was explained by a higher degree of food processing. In contrast, ultra-processed food intake remained associated with mortality even after the poor nutritional quality of the diet was accounted for.

Both studies are observational, and therefore can’t establish cause. Limitations include the possibility that some of the risks may be due to other unmeasured (confounding) factors. 

Nevertheless, both studies used reliable markers of dietary quality and took account of well-known risk factors, and the findings back up other research linking highly processed food with poor health outcomes.

As such, both research teams say their findings support the public health importance of limiting certain types of ultra-processed foods for better health outcomes in the global population. Results from the Italian study also reinforce the opportunity to reformulate dietary guidelines worldwide, by paying more attention to the degree of processing of foods along with nutrient-based recommendations.

In a linked editorial, Brazilian researchers argue that nobody sensible wants foods that cause illness.

The overall positive solution, they say, includes making supplies of fresh and minimally processed foods available, attractive, and affordable. And sustaining national initiatives to promote and support freshly prepared meals made with fresh and minimally processed foods, using small amounts of processed culinary ingredients and processed foods.

“Enacted, this will promote public health. It will also nourish families, society, economies, and the environment,” they conclude.


“Association of ultra-processed food consumption with colorectal cancer risk among men and women: results from three prospective US cohort studies” by Lu Wang, Mengxi Du, Kai Wang, Neha Khandpur, Sinara Laurini Rossato, Jean-Philippe Drouin-Chartier, Euridice Martínez Steele, Edward Giovannucci, Mingyang Song and Fang Fang Zhang, 31 August 2022, The BMJ.
DOI: 10.1136/bmj.o1972

“Joint association of food nutritional profile by Nutri-Score front-of-pack label and ultra-processed food intake with mortality: Moli-sani prospective cohort study” by Marialaura Bonaccio, Augusto Di Castelnuovo, Emilia Ruggiero, Simona Costanzo, Giuseppe Grosso, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano and Licia Iacoviello on behalf of the Moli-sani Study Investigators, 31 August 2022, The BMJ.
DOI: 10.1136/bmj-2022-070688

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.