Mallinckrodt Pharmaceuticals, the largest generic opioid manufacturer in the United States, has tentatively agreed to pay $1.6 billion to settle thousands of lawsuits brought by state and local governments over its role in the opioid crisis.

The agreement was endorsed by 47 states and U.S. territories along with a committee of lawyers representing thousands of cities and counties, the company said on Tuesday.

The money, to be paid into a cash trust over eight years, will be used to underwrite the costs of opioid addiction treatments and related efforts across the country.

“Nothing can undo the devastating loss and grief inflicted by the opioid epidemic upon victims and their families, but this settlement with Mallinckrodt is an important step in the process of healing our communities,” Attorney General Xavier Becerra of California said in a statement announcing the agreement. “Our office has worked aggressively to hold accountable bad actors who fueled this public health crisis.”

Under the terms of the agreement, the United States division of Mallinckrodt that produces generic opioids would file for Chapter 11 bankruptcy. After a bankruptcy judge approves the restructuring plan, an initial payment of $300 million would be disbursed to plaintiffs to alleviate the opioid crisis, with the remaining $1.3 billion to be paid out over eight years.

Other divisions of the company, which has its headquarters abroad and also produces branded drugs, are not filing for bankruptcy.

Mallinckrodt is the first opioid company to reach even a tentative national settlement agreement with municipal governments and most of the states. Offers from other defendants — like Purdue Pharma, the maker of OxyContin, which, like Mallinckrodt, is now also seeking to restructure in bankruptcy court, and from the health and consumer products giant Johnson & Johnson and huge drug distributors like McKesson — have yet to be accepted by an overwhelming majority of plaintiffs.

The Centers for Disease Control and Prevention said that from 1999 to 2017, almost 218,000 people died in the United States from overdoses related to prescription opioids. The opioid-related deaths were five times higher in 2017 than they were in 1999, according to the C.D.C.

In a statement, Paul T. Farrell Jr., Paul J. Hanly Jr. and Joe Rice, lawyers who are negotiators on behalf of thousands of cities and counties suing the company in federal courts, said that though they had agreed to the deal in principle, they were still working out the details.

“Our pursuit of corporate accountability against a host of other defendants across the entire drug supply chain will not stop,” the lawyers said.

New York is one of the few states that have not yet confirmed acceptance of the Mallinckrodt offer. Its trial, which is being joined by Suffolk and Nassau Counties, against a cluster of pharmaceutical industry defendants, including Mallinckrodt, is set to begin on March 20.

In a statement, Letitia James, the New York attorney general, said: “While we continue to work with other states and creditors to ensure that any proposal involving Mallinckrodt serves the interests of our communities and that money can flow to our communities for remediation as quickly as possible, we have yet to reach a final agreement with the company on all terms of a New York settlement. Unless that happens, we are determined to press ahead with the trial against the company next month.”

With the Los Angeles County Museum of Art just weeks away from demolishing four buildings on its campus to make way for a $650 million structure by Peter Zumthor, the Ahmanson Foundation said Tuesday that it is suspending its decades-long program of buying art for the museum over concerns about the effects of the radical redesign.

In a telephone interview William Ahmanson, president of the foundation, said he fears that under the Zumthor plan — a sweeping, one-level structure designed to flatten the traditional museum hierarchies that privilege particular centuries and cultures — many European artworks his family’s foundation donated will end up in storage.

“It’s my understanding that LACMA is changing from an encyclopedic museum with a robust permanent collection to a museum with some permanent collection works on view and more temporary exhibitions,” Mr. Ahmanson, who remains a board member there, said. “The concern is that the carefully curated collection we’ve amassed over decades may never see the light of day again.”

The foundation’s decision was first reported by The Los Angeles Times.

Starting in 1972, the Ahmanson Foundation has spent about $130 million to finance the museum’s acquisitions of 99 artworks, including masterpieces like “The Magdalen With the Smoking Flame” by Georges de La Tour, others by Rembrandt, Watteau and Bernini, and a suite of 42 French oil sketches. The donations were not made with any contractual stipulations that the works remain on view. But historically, Mr. Ahmanson said, “nearly all” of the works except for the light-sensitive French sketches have been on display at any given time.

“I have been asking how much space is going to be dedicated to the permanent collection, of which European art is a large portion, and I haven’t been able to get that information,” Mr. Ahmanson said, noting that the foundation had decided against an acquisition the museum proposed in 2019 for this reason and “will not consider other requests for art from LACMA for now.”

He said the foundation received a letter from the museum’s director, Michael Govan, in 2006 promising “at least equal and probably much better space” for the art in the new building. But since then, amid debate over whether the museum is forfeiting exhibition space in its new design, assurances have not been as convincing, Mr. Ahmanson said.

Mr. Govan said by phone on Tuesday that it’s impossible at this stage to provide any square footage figures for particular material, which will evolve with his curators’ choices. But, he said: “We could not be more enthusiastic to present the Ahmanson works at the core of our collections as they always have been. I believe that some of people’s favorite masterpieces from this group will be even more prominently displayed because of the more accessible arrangement of galleries in the new building.”

The Arashiyama Bamboo Forest, one of the most visited sites in Kyoto, Japan, was quiet enough to hear the bamboo creaking in the wind.

The Ngong Ping 360 cable cars in Hong Kong, which hover over Lantau Island and take passengers to a famous Buddha statue, hung motionless and empty.

The crush of flag-following tour groups that usually cram the Lantern Bridge in Hoi An’s ancient town in central Vietnam had disappeared.

And in Siem Reap, home to the ancient ruins of Angkor Wat in Cambodia, the usually busy Sala Lodges hadn’t had a new booking in three weeks.

The coronavirus epidemic is taking its toll on global tourism, which according to the World Travel & Tourism Council contributed $8.8 trillion to the world economy in 2018. Some economists say the epidemic could be the biggest drag on global economic growth since the financial crisis, with airlines alone expected to lose some $29 billion in revenues this year.

The Asian countries closest to China, which is the epicenter of the outbreak and the world’s leading source of international travelers and tourism spending, are feeling the brunt of the crisis, but the effects are spreading. On Sunday, Venice cut short its annual carnival celebration, and the Italian government shut down travel to 10 towns in the Lombardy region after a surge in new cases there.

In recent years, countries in Southeast Asia invested heavily in resorts and casinos to capture the swelling ranks of Chinese tourists. Now airlines, hotels and tour operators are suffering from a rush of cancellations and a drop in future bookings, primarily from mainland China, but also from Western travelers spooked by the spread of the virus in the region.

The economic toll is mounting: Countries that have relied heavily on Chinese tourism, including Vietnam, Thailand, Cambodia, Malaysia and Singapore, are each expected to lose at least $3 billion in tourism-related revenues, according to an analysis by Animesh Kumar, a travel and tourism director at GlobalData, a research and consulting firm based in London.

The steep losses are mostly because of the absence of Chinese tourists, but also because some “tourists from other countries are apprehensive about traveling anywhere close to China,” he wrote in his report.

A report last week from Hopper, the flight and hotel booking app, showed a decline in searches by Americans in the past several weeks for flights to Asian countries, especially China. Its analysis of billions of airfare quotes from across the internet showed a roughly 20 percent drop in demand to Malaysia, Singapore and Vietnam. The company said it was seeing a shift in Americans searching for domestic destinations over international locales.

The Coronavirus Outbreak

What do you need to know? Start here.

What is a Coronavirus?
It is a novel virus named for the crown-like spikes that protrude from its surface. The coronavirus can infect both animals and people, and can cause a range of respiratory illnesses from the common cold to more dangerous conditions like Severe Acute Respiratory Syndrome, or SARS. How contagious is the virus?
According to preliminary research, it seems moderately infectious, similar to SARS, and is possibly transmitted through the air. Scientists have estimated that each infected person could spread it to somewhere between 1.5 and 3.5 people without effective containment measures. Where has the virus spread?
The virus originated in Wuhan, China, and has sickened tens of thousands of people in China and at least two dozen other countries. How worried should I be?
While the virus is a serious public health concern, the risk to most people outside China remains very low, and seasonal flu is a more immediate threat. Who is working to contain the virus?
World Health Organization officials have praised China’s aggressive response to the virus by closing transportation, schools and markets. This week, a team of experts from the W.H.O. arrived in Beijing to offer assistance. What if I’m traveling?
The United States and Australia are temporarily denying entry to noncitizens who recently traveled to China and several airlines have canceled flights. How do I keep myself and others safe?
Washing your hands frequently is the most important thing you can do, along with staying at home when you’re sick.

Chinese travelers racked up an unprecedented 150 million trips abroad and spent more than $277 billion on international travel in 2018. But the juggernaut last year sputtered in the wake of slower economic growth and the trade war with the United States. It effectively came to a halt as the coronavirus epidemic led the government to bar groups of tourists from traveling abroad, and dozens of international carriers like American Airlines and United Airlines suspended flights to mainland China.

As the virus continues to spread, the Centers for Disease Control and Prevention on Saturday issued Level 2 alerts for Japan and South Korea, advising older adults and those with chronic conditions to “consider postponing nonessential travel.” On Wednesday, Hong Kong received a Level 1 watch advising travelers to take precautions like washing hands and avoiding sick people.

Jenni Honkanen and Tobias Solvefjord, both 39, of Skovde, Sweden, were on a half-full jet from Hong Kong to Ho Chi Minh City on Wednesday morning, wondering if sites would be closed or travel restricted. Still, the couple were not overly concerned.

They were aware that Vietnam had reported only a small number of cases (16 compared with more than 77,000 in China) and joked that it wouldn’t be bad being quarantined in the tropics instead of suffering through the bleak winter in Skovde.

“We’ll be fine,” Ms. Honkanen said. “Vietnam should still be fine, hopefully.”

In one of the country’s most popular destinations, Hoi An, the scene last weekend was as if the former port city had returned to the days before package tours and fleets of tour buses clogged the streets, said resident Patricia Clegg, 64, a native of France whose parents are from Vietnam.

China and South Korea have been the biggest sources of tourists for the town in the past few years as sprawling resorts filled the coast between the town and Danang, about 20 miles north.

“All the Asian tourism has mostly disappeared,” said Ms. Clegg, a consultant for the town’s oldest tailor shop catering to tourists, Yaly. “It’s mostly Western tourists now.”

At Reaching Out handicraft shop in Hoi An’s ancient town, business is down 65 percent since the coronavirus hit the news and by 45 percent at its teahouse, said the owner, Le Nguyen Binh, 56. One-third of the staff is on leave and collecting unemployment until sales pick up. The 40 remaining staff members have their temperatures taken when they arrive to work and don masks, which are also offered to customers, along with hand sanitizer, Mr. Binh said.

In the midst of Japan’s historic tourism boom, February in Kyoto would normally see streets and parks filled with tourists — largely Chinese nationals visiting as part of tour groups — taking in the first plum blossoms in the former ancient capital. Chinese visitors supplied one-quarter of Japan’s record 32 million arrivals in 2018. Instead, the popular Chion and Nison temples were nearly void of sightseers. Katsunobu Kato, Japan’s health minister, has urged the public to “avoid nonurgent, nonessential gatherings.”

In Hong Kong, the Tourism Board chief, Dane Cheng, said tourism would take a bigger hit than it did during the outbreak of severe acute respiratory syndrome, or SARS, that struck the territory and mainland China 17 years ago. In the first two weeks of February, only 3,000 tourists a day visited Hong Kong, he said. In January, the city averaged about 65,000 tourists a day, a number that was already down because of months of political protests and a shrinking economy.

“It’s a huge drop,” Mr. Cheng said. “This time it’s not just Hong Kong, but all or most parts of Asia.”

In Hong Kong, where 68 cases of the new disease, formally known as Covid-19, have been confirmed, government-run tourism sites like the harbor-front Hong Kong Museum of Art, the marine-life theme park Ocean Park and the Ngong Ping 360 cable cars have been closed. Events like Art Basel Hong Kong have also been canceled.

Tim Cheung, who was handing out fliers on Thursday evening for his restaurant in Lan Kwai Fong, Hong Kong’s popular night life district, said businesses there had already taken a hit during the protests and were worse off now, with business dropping 70 to 80 percent since the Chinese New Year.

“Basically we don’t know what will happen tomorrow,” he said. “I may be out of a job. I’ll work another day for as long as I can. Many Hong Kongers are like this now.”

Singapore, which has reported 89 coronavirus cases, announced a fiscal boost of several billion dollars to help households and sectors like aviation and tourism that are most affected by the outbreak.

Jewel, a nature-themed complex at the Changi Airport, reflected the malaise. At the Rain Vortex indoor waterfall, usually crowded with people jostling to take selfies, there was plenty of space to take a photo alone. Apple Store employees in their dark blue T-shirts outnumbered shoppers two to one.

Jeanne Liu, the owner of Rich & Good Cake Shop, which has an outpost at Jewel, said that business was down by half. “The general mood in the country is depressed, and people aren’t going to places they perceive as crowded,” she said.

Robert and Jane Murray, 73 and 70, who live in Australia, were sitting in a mostly empty Terminal 3, waiting for their flight to Jaipur, India, to attend a wedding after spending three days in Singapore.

“We booked the trip before all the hype, and it made us want to cancel,” Mr. Murray said. “But we contacted our doctor, who said ‘It’s just like the flu,’ so we just take precautions, wash hands and we’re fine.”

In Cambodia’s usual tourist hot spot, Siem Reap, the airport was hauntingly empty and check-in and security lines were minimal.

Arne Lugeon, 56, the French-born owner and general manager of the Sala Lodges, said that as of mid-Feburary, its 11 traditional wooden houses had not had a new booking in three weeks, even though February is high season for tourism. “I can only hope this virus is contained and then ends soon,” he said.

Fabien Martial, 46, co-owner of the 35-room Viroth’s Hotel, said: “During the Chinese New Year, 70 percent of our clients are from China, but this year they all canceled. The hotel was nearly completely empty for a few days.”

“I’ve been a hotelier here through SARS, avian flu and political unrest,” Mr. Martial added. “I’ve learned to be patient and to endure. Business and tourism will be back.”

In Thailand, which receives, by far, the most Chinese tourists in Southeast Asia, with more than 10 million in 2018, the Platinum Mall in Bangkok is typically bustling this time of year, said Siriwan Saensuwan, 65, who has been selling clothes there for a decade. But for the past couple of weeks, she said, “it has been quiet, like a cemetery.”

“Look for yourself,” she said, “no one is walking around.”

Reporting was contributed by Elaine Yu from Hong Kong; Adam H. Graham and Allan Richarz from Tokyo and Kyoto, Japan; David Farley from Siem Reap, Cambodia; Sanjay Surana from Singapore; and Muktita Suhartono from Bangkok.

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